ea0034p243 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014
Verma Manu
, Zhang Zhenguang
, Mackellar Annie
, Seckl Jonathan
, Holmes Megan
, Chapman Karen
Chronically elevated glucocorticoid (GC) levels alter cognition and increase cardio-metabolic disease risk. Negative feedback suppression of the hypothalamicpituitaryadrenal (HPA) axis, including at the hippocampus, maintains low/basal circulating GC levels. Intracellular GC can be increased, without alteration in circulating levels, by the activity of 11β-hydroxysteroid dehydrogenase type1 (11β-HSD1). In some tissues, 11β-HSD1 expression is increase...